HANC Newsletter  |  March 2022

Land, Labor, and Justice Acknowledgements

We acknowledge the land we occupy today as the traditional home of the Duwamish, Tulalip, Muckleshoot, and Suquamish tribal nations, the original caretakers of this land who are still here. Without them we would not have access to this working, teaching, and learning environment. We commit to conducting ourselves with dignity and treating this land and all the life it sustains with respect. We ask you to join us in this commitment, wherever you may reside. We also acknowledge exploited labor and ongoing struggle​s for justice on this land. We reflect on the ancestors of our various peoples, nations, tribes, and families; ancestors whose struggles, pain, power, privilege, and strivings we hold in our very bodies.

HANC offices are located at Fred Hutch campus in Seattle, WA.
 

H=H Episode 4: The Health of Transgender People

Episode 4 of the H=H the H is for Human podcast is ready to download.  In this episode we have a conversation with Jessica Xavier, activist, advocate and researcher, and Maria Roman-Taylorson, Chief Executive Officer of TransLatin@ Coalition, to discuss the health of transgender women.  Join the conversation by clicking here .

 
Join us in recognizing the following HIV/AIDS Awareness Days this month:
 

March 10: National Women and Girls HIV/AIDS Awareness Day

The theme for 2022 is Prevention and Testing at Every Age. Care and Treatment at Every Stage. In the U.S., about 23% of people living with HIV are women and, in 2018, women made up 19 percent of new diagnoses. The highest number of new diagnoses were among women ages 25 to 44. Advances in testing, treatment, and prevention have resulted in progress towards the nation’s goal to end the HIV epidemic by 2030.

The Women's HIV Research Collaborative (WHRC) developed an infographic to commemorate the day. Please enjoy and share. 
 
 

March 20: National Native HIV/AIDS Awareness Day

The theme for 2022 is Reflection. Celebration. Rejuvenation. The observance of NNHAAD is a national mobilization effort designed to encourage Native people (American Indians, Alaska Natives, and Native Hawaiians) across the U.S. and Territorial Areas to get educated, get tested, get involved in prevention, and get treated for HIV.
 
The ACTG March newsletter is now available here.

Congratulations to Dr. Sikhulile Moyo, PhD, MSC, MPH from our Gaborone CRWS in Botswana on being awarded the MILK Honoree International Humanitarian Service Award at the 32nd Annual Rev. Martin Luther King Jr. celebration last month! You can watch the recording of the live presentation HERE.

The ACTG would like to congratulate Amita Gupta, MD, MHS on being named the seventh director of Johns Hopkins Medicine's Division of Infectious Diseases! Dr. Gupta is a long time ACTG investigator, taking on many roles within the network. Most recently, she is the study chair on A5300 (MDR TB Feasilibility) and A5300B (MDR TB Households) and the vice chair on A5274 (Empiric TB Tx) and A5279 (BRIEF TB). You can read more HERE.
 
 
The 2022 HPTN Annual Meeting will take place at the JW Marriott June 5-8, 2022, in Washington, D.C. At present, we are planning for an in-person meeting with a virtual participation option for those unable or who choose not to attend in person. The Annual Meeting will feature several plenaries, presentations, and discussions regarding HIV and COVID-19 prevention research, and interactive question and answer sessions.

Are you planning to attend in person or virtually?

To help you make an informed decision about how you will attend, we will share comprehensive COVID-19 safety protocols closer to the Meeting date. For now, please consider the following information: 

Online registration will be announced in the coming weeks.
 
IMPAACT P1107 at CROI 2022: First Woman in HIV Remission
The IMPAACT Network presented 17 abstracts from 12 studies (3 oral presentations, 14 poster presentations) at the Conference on Retroviruses and Opportunistic Infections (CROI), from 12-16 February 2022.

Notably were data presented from IMPAACT P1107. The IMPAACT P1107 Protocol Team presented the first known case of a woman with HIV remission, following a stem cell transplant for treatment of acute myelogenous leukemia (AML). The transplant consisted of cord blood stem cells with the CCR5Δ32 genetic mutation and haploidentical peripheral blood stem cells from a relative.

The participant’s HIV was well-controlled on antiretroviral therapy (ART) prior to the stem cell transplant and through 37 months post-transplant, at which time she stopped ART. With the exception of transient detection of trace levels of HIV-1 DNA in blood cells 14 weeks after stopping ART, no HIV has been detected for 14 months. Based on these results, the participant has been deemed in HIV remission. Learn more and see press coverage from the results.

Learn more about other IMPAACT abstracts presented as oral presentations and as poster presentations at CROI 2022.
 
2022 Hybrid IMPAACT Annual Meeting
The 2022 IMPAACT Annual Meeting will take place as a hybrid conference to include both virtual and in-person participation from 28 June - 01 July 2022. The in-person component will be hosted at the Washington Hilton Hotel in Washington, D.C., USA. Visit the 2022 Annual Meeting webpage to learn more about COVID-19 protocols to assess whether you prefer to join in-person or virtually.
The HANC-facilitated COVID-19 CAB Coalition (CCC) formed in September 2020 to share information, share resources, and advocate on behalf of COVID-19 research efforts. Members represent the COVID-19 Prevention Network (CoVPN) Community Engagement Working Group, the ACTG's ACTIV-2 CAB, AVAC's COVID Advocates Advisory Board, the CFAR National CAB Coalition, the COVID-19 CAB at Stony Brook, DAIDS, and Community Partners.

Updates from the CCC are shared below:
 
COVID-19 CAB Coalition Update
The COVID-19 CAB Coalition has formed an ad-hoc working group to draft brief scripts on understanding science. The scripts will be used to create short, animated videos to share on social media. The group will likely finalize the first three scripts during the next meeting.
On February 23, 2022, Sanofi and GSK announced that they intend to submit data from both their booster and Phase 3 efficacy trials as the basis for regulatory applications for a COVID-19 vaccine. Read the full press release here.
Find frequently asked questions about vaccines, vaccine boosters, COVID-19, and the Pfizer vaccine for children aged 5-11 here.
Behavioral and Social Sciences

Greg Davis, HANC Project Manager
The Youth Prevention Research Working Group is planning a webinar with international investigators that participated in the HPTN Scholars Program. The webinar will likely be held in April. More information will be shared with HANC collaborators soon.

The Behavioral Science Consultative Group (BSCG) will convene for a meeting on March 11, 2022. The group is finalizing the agenda for the meeting. 
 
Community Partners

Russell Campbell, HANC Deputy Director
CP has been invited to present to the IMPAACT CAB (ICAB) in March to promote the mission and purpose of Community Partners (CP), including the various training materials developed by CP and how to access those resources and materials.

CP members have been involved in discussions with clinical research site staff and other community representatives to discuss ways for sites to meaningfully engage CAB members and ways for sites and community members to support each other in light of the ongoing challenges of the COVID-19 pandemic.
 
Cross-Network Coordination

Milan Vu, HANC Project Manager
The Cross-Network Site Coordinators Working Group (SCWG) held a joint meeting with members of Community Partners (CP) and local CAB liaisons to discuss strategies for site-CAB engagement during the ongoing COVID-19 pandemic.

HANC has convened an ad-hoc, cross-network working group to address COVID-19 issues and safety at the upcoming annual network meetings in May - July 2022. Members on the group include representatives from each network's meeting planning committees, DAIDS, Community Partners, and international site staff.
 
Laboratory Coordination

Tyler Brown, HANC Project Manager
The CPQA Cross-Network Clinical Pharmacology Forum (CNCPL Forum) held a meeting in February to discuss future network study compounds, implementation of the CPQA Program’s new proficiency testing acceptance criteria window, and a presentation by Dr. Richard Browne (of the University of Buffalo) highlighting the potential for error in Darunavir Ethanolate purity calculations.

The Lab Focus Group (LFG) held a meeting in February with members of the DAIDS Clinical Laboratory Oversight Team (DCLOT), pSMILE, and PPD to discuss reagent and lab supply shortages and plans to develop site-level guidance on these issues.

The HANC-CPQA Qualitative Assay Working Group met in February to continue drafting a new set of guidelines for qualitative ARV pharmacology assays – guidelines are expected to be published by this summer.
 
The Legacy Project

Brian Minalga and Pedro Goicochea, HANC Community Engagement Officers
The Legacy Project had two articles published last month. Please enjoy, apply, and share!
  • Minalga, Brian; Chung, Cecilia; Davids, JD; Martin, Aleks; Perry, Nicole Lynn; and Shook, Alic (2022). “Research on Transgender People Must Benefit Transgender People,” The Lancet. Vol 399: Iss. 10325, P. 628. Available at: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02806-3/fulltext 
  • Spieldenner, Andrew; French, Martin; Ray, Venita; Minalga, Brian; Sardina, Christine; Castro-Bojorquez, Marco; Lewis, Octavia; and Sprague, Laurel (2022). “The Meaningful Involvement of People with HIV/AIDS (MIPA): The Participatory Praxis Approach to Community Engagement on HIV Surveillance,” Journal of Community Engagement and Scholarship. Vol. 14: Iss. 2, Article 1. Available at: https://digitalcommons.northgeorgia.edu/jces/vol14/iss2/1/ 
March 1: The latest edition of the Be the Generation newsletter is now available featuring community-focused updates from the HPTN, HVTN, and HANC.

March 10: The Legacy Project recognizes National Women and Girls HIV/AIDS Awareness Day. Please enjoy and share the Women’s HIV Research Collaborative’s infographic commemorating the day. 

March 15: Episode 5 of the “H=H, the H is for Human” will be devoted to clinical research involving transgender people.  You can access the podcast on March 15 here.

March 20: The Legacy Project recognizes National Native HIV/AIDS Awareness Day.

March 24: The Latinx Caucus will be presenting the abstract “Community Involvement in HIV Prevention Clinical Research” at the National Latinx on HIV/HCV/SUD
 

Webinars

March 17, 2022 at 8:00am PT / 11:00am ET / 5:00pm SAST
The Office of HIV/AIDS Network Coordination (HANC) invites you to join us in a two-part webinar program exploring the use of electronic informed consent (e-consent) in clinical research. Part one, eConsent 101: Regulatory Foundations looks at the basics of what e-consent is, how it is used, and what regulations govern its use. Featured speakers include subject matter experts from the Division of AIDS (DAIDS) Protection of Participants, Evaluation, and Policy Branch (ProPEP) and Dr. Jose Pablo Morales from the U.S. Food and Drug Administration (FDA).  Register here.
March 23, 2022 at 8:00am PT / 11:00am ET / 5:00pm SAST
A discussion with Dr. Sikhulile Moyo of the Botswana-Harvard AIDS Institute Partnership Laboratory about his work on SARS-CoV-2 genomic surveillance and his team’s discovery of the Omicron variant. Register here.
March 28, 2022 at 8:00am PT / 11:00am ET / 5:00pm SAST
Part two of the HANC eConsent in Practice webinar series explores real-world experiences with e-consent in clinical research studies, providing insights from clinical research sites who have done it firsthand and discussing considerations for implementing e-consent at research sites. Register here.
 

Training

Various Dates, February - July 2022

The UW/Fred Hutch Center for AIDS Research (CFAR), UW Indigenous Wellness Research Institute (IWRI), and the University of Hawaii (UH) have launched a new project titled “Building Indigenuity, Generating HIV Science: HIV/AIDS Research Training (BIG HART).” This exciting new training opportunity will be led by Karina Walters, MSW, PhD (Choctaw Nation of Oklahoma), Co-Director of IWRI, Professor and Associate Dean in the School of Social Work, and Jen Balkus, PhD, MPH, CFAR DEI Lead and Assistant Professor in the Department of Epidemiology in the School of Public Health.  

BIG HART will host a six-part seminar series for Indigenous undergraduate and graduate students at UW and UH who are interested in learning more about HIV research and the various ways the epidemic impacts Indigenous communities across North America. The series will feature both scientists and practitioners working across the spectrum of HIV science, including former scholars from the Indigenous HIV/AIDS Research Training Program (IHART). The monthly sessions will be held in February through July of 2022. Among those who attend at least one session, interested students will be given the opportunity to participate in a one-on-one mentorship session with an IHART mentor and/or CFAR investigator. In addition, up to 10 graduate students will also have the opportunity to participate in the UW Principles of HIV/STI Research and Public Health Practice Course.

Interested students can join this BIG-HART listserv to stay up to date on all BIG HART activities and opportunities. The speaker list and schedule will be made available on the website once finalized, and Zoom registration is now open to all! Please reach out to Jen Balkus (jbalkus@uw.edu) or Karina Walters (kw5@uw.edu) with any questions about the project, or Anya Lewin (lewina@uw.edu) with any administrative questions.  
 

Conferences & Meetings

March 24-26, 2022
National Latinx Conference on HIV, HCV, & SUD (Hybrid: Albuquerque, NM USA)
May 4-6, 2022
HVTN Full Group Meeting (Hybrid: Washington, DC USA)
June 4-8, 2022
HPTN Annual Meeting (Hybrid: Washington, DC USA)
June 13-17, 2022
Annual ACTG Network Meeting (Hybrid: Washington, DC USA)
June 28-July 1, 2022
IMPAACT Annual Meeting (Hybrid: Washington, DC USA)