TABLE OF CONTENTS
HANC ANNOUNCEMENTS
NETWORK ANNOUNCEMENTS
HANC PROGRAM UPDATES
CONFERENCES AND MEETINGS
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ACTG & HPTN
Annual Network Meetings
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The overlapping ACTG and HPTN Annual Network Meetings this year were a fantastic opportunity to learn from the two different networks. Team Legacy members Brian Minalga and Cat Banobi got the benefit of participating in both conferences.
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Their words are inspiring for the future of the network and the goal of ending the HIV epidemic.
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Heading across town to HPTN the team then enjoyed a joint plenary from the two networks. HANC’s network coordination hearts were happy to see the sharing of knowledge across networks! Among other topics, the audience heard about critical factors for improving outcomes for key populations, addressing drug resistance, and different ART and PrEP options. One of the upcoming studies to improve outcomes for key populations is HPTN 113 (DUO), and the study team was kind enough to
chat with Team Legacy about what their study will do and why it’s important. More to come from this important study!
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More also to come from both networks regarding recurring topics at the meetings such as engaging young people, emphasizing HIV and aging, and the need for robust implementation science and behavioral science as efforts continue to ensure that interventions are as successful as possible for key populations.
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ACTG Annual Network Meeting 2024
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The 2024 annual meeting was held at the Omni Shoreham hotel in Washington DC from June 12-16. Over 500 participants gathered from around the globe to share highlights and information about their work with their colleagues.
Congratulations to the many
2024 ACTG Award Winners!
JOHN CAREY YOUNG INVESTIGATOR AWARD For Outstanding Service to Advancing Clinical Therapeutics Globally and for Research Advancing the Care of People Living with HIV/AIDS was presented to Jason Zucker, MD, MS.
CHARLES VAN DER HORST HUMANITARIAN AWARD For Outstanding Service to Advancing Clinical Therapeutics Globally and for Research Advancing the Care of People Living with HIV/AIDS was presented to Karine Dubé, DrPH, MPhil.
CONSTANCE B. WOFSY WOMEN’S HEALTH INVESTIGATOR AWARD In Recognition of Scientific Contributions to Research in Women Living with HIV and Embodiment of Qualities Exemplified by Dr. Wofsy was presented to Lameck Chinula, MD, MMED, FCOG(SA).
DONNA DAVIS COMMUNITY AWARD For Outstanding Service to the Community of Advancing Clinical Therapeutics Globally and for Caring about People Living with HIV/AIDS was presented to Judith Currier, MD, MSc.
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HVTN Attending AIDS 2024
The HVTN will be presenting data from a number of vaccine and broadly neutralizing antibody studies at the upcoming AIDS 2024 conference in Munich, July 21-26, 2024. In addition to the posters listed below, the HVTN will be hosting a satellite session, “Broadly neutralizing antibodies for the prevention of HIV in adolescents and adults”, on Tuesday, July 23, at 6:00 pm in Room 5 (Hybrid channel 8) chaired by Dr. Larry Corey and Dr. Nono Mkhize. The satellite agenda is available
HERE.
We are also joining together with the HPTN to host a Networking Zone in the Global Village, “Help end HIV: clinical trials for HIV prevention” (booth # HT06). If you will be in Munich, plan to stop by the Global Village to join us for one of more than 30 presentations that will be offered throughout the week, including meeting members of the network staff, site investigators, network leaders, and Dr. Carl Dieffenbach, Director of the Division of AIDS. There will also be presentations offered in Spanish.
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IMPAACT Network Presentations at the International Workshop on Pediatrics & HIV and AIDS 2024
Several IMPAACT Network researchers will present study findings in Munich, Germany this month at the International Workshop on Pediatrics & HIV and AIDS 2024. Please see a list of the accepted abstracts below. Once the embargoes have been lifted, the presentations will be shared on IMPAACTNetwork.org.
International Workshop on Pediatrics & HIV (19-20 July 2024)
· IMPAACT 2023 (oral presentation): Pharmacokinetics and Safety of Dolutegravir in Neonates Exposed to HIV-1 (IMPAACT 2023)
· IMPACCT 2016 (poster presentation): High prevalence of common mental disorders amongst adolescents with HIV in Zimbabwe: IMPAACT 2016, A Randomized Control Trial
· IMPAACT 2009 (poster presentation): Site experiences delivering integrated Next Step Counseling (iNSC) to perinatal participants in the IMPAACT 2009 study in Zimbabwe
AIDS 2024 (22-26 July 2024)
· IMPAACT 2017 (oral presentation): Long-acting cabotegravir (CAB) plus rilpivirine (RPV) in the first, virologically-suppressed adolescents with HIV-1 to receive an every 8-week, all-injectable regimen in a multicenter, multinational study: IMPAACT 2017 Week 48 outcomes
· IMPAACT 2009 and P1026s (poster presentation): Prediction of reduced intracellular tenofovir-diphosphate concentrations during pregnancy using a semi-mechanism-based population pharmacokinetic model
IMPAACT Network Annual Meeting
Save the date! This year’s Annual Meeting will be held 22-27 September 2024 at the Crystal Gateway Marriott in Arlington, VA. If you require a visa letter to attend the meeting, please submit this form as soon as possible. An iterative agenda will be available on the
Annual Meeting page mid to late July. Please visit the page often as more information and resources will be added. We look forward to seeing you there!
IMPAACT Network Manual of Procedures Update
The IMPAACT Network has updated and finalized Version 5.0 of the Network Manual of Procedures, dated 31 May 2024. Individual sections and a combined version are available here. Please refer to the “Overview of Section Contents and Summary of Changes” for information on key updates.
IMPAACT 2019 Helps European Medicines Agency Approve Triumeq PD® for Infants and Young Children
The IMPAACT Network is pleased to announce that based on study data from IMPAACT 2019, the European Medicines Agency has approved Triumeq PD® for infants and children as young as 3 months of age who weigh at least 6 kg. You may read the full announcement here
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This year's meeting brought together hundreds of researchers, community representatives, partner organizations, and funders to discuss the Network's scientific agenda and the state of HIV prevention research. Attendees (in-person and virtual) received updates on HPTN research and new information in the HIV prevention field, helping move the science forward. Our HPTN Community Working Group sessions started the meeting with an abstract writing workshop, best practices for community engagement, and presentations on the latest HIV prevention research.
We were excited to partner with the ACTG for a special joint plenary session on Sunday morning, June 16. The presenters from both networks shared critical insights on several topics related to HIV treatment and prevention. These insights were informative and engaging, sparking discussions and further exploration. The morning's agenda concluded with a plenary session showcasing the work of HPTN Domestic and International Scholars, spotlighting the development of the next generation of HIV prevention investigators within the HPTN.
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On Monday morning, June 17, our plenaries explored the ideas of 'Building the Prevention Toolbox' and 'Using the Prevention Toolbox,' an opportunity to look at novel HIV prevention strategies and how proven strategies can be effectively implemented. In the evening, we hosted our traditional welcome gathering and poster session, a unique chance to connect with colleagues and discuss the work done at our research sites worldwide.
The Annual Meeting culminated on Tuesday morning, June 18, with the HPTN State of the Network plenary address, a 'not-to-be-missed' opportunity to understand and anticipate the Network's progress and future direction. The session also included updates from the U.S. National Institutes of Health's National Institute of Allergy and Infectious Diseases and the Division of AIDS leadership, further fueling the anticipation for the future of HIV prevention research. The session concluded with the Ward Cates Spirit Award and Network Awards presentations, inspiring the audience with the recognition of outstanding contributions.
The next HPTN Annual Meeting is scheduled for May 31-June 4, 2025, in Crystal City, Va.
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Behavioral and Social Sciences
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Greg Davis
HANC
Project Manager
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Behavioral Science Consultative Group: The Behavioral Science Consultative Group (BSCG) is continuing to plan for the upcoming face-to-face meeting on August 2 in Seattle, WA.
Financial Disclosure Working Group: The Financial Disclosure Working Group recently finalized the SOP
for the upcoming annual solicitation. The annual solicitation will take place on September 20, 2024.
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Greg Davis
HANC
Project Manager
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Russell Campbell
HANC Director
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Community Partners: Community Partners will meet face-to-face in September. The two-day meeting will take place in Crystal City, VA before the IMPAACT annual network meeting. CP looks forward to having a conversation with Dr. Carl Dieffenbach during the face-to-face meeting. The Community Partners Executive Committee will be reviewing a draft agenda in the coming weeks.
TB Vaccine Community Engagement Strategy WG: HANC submitted an abstract to the Union World Conference on Lung Health on behalf of the TB Vaccine Community Engagement Strategy Working Group. More information will be shared when/if the abstract is accepted.
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Cross-Network Coordination
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Kathleen Pescasio
HANC Cross-Network
Project Manager
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The Cross-Network Site Coordinators Working Group (SCWG) recently discussed insights from the ACTG and HPTN Annual Meetings. The group raised the topics of strategies for site success, training and mentorship needs, and challenges with staff turnover as the research landscape expands. Group members shared valuable input on the benefits of real-time support and community engagement, and various action items were proposed. The SCWG will continue to discuss best practices for improving communication lines and support structures across networks.
The Cross-Network Data Management Center Working Group (DMCWG) discussed several ongoing initiatives and updates on survey software tools and study engagement systems. Frontier Science is progressing with their pilot of Medidata Detect, and SCHARP shared their completion of a pilot project for EMR data extraction. The DMCWG discussed the new DAIDS policy on eCRF Data Review and Investigator Sign Off.
The Cross-Network Evaluation Working Group (EWG) continues to discuss standardization for evaluation metrics and reporting within the networks. The EWG will review and discuss the recent guidance provided by OCSO leadership during their next meeting.
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Tyler Brown
HANC Laboratory
Project Manager
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The CPQA Cross-Network Clinical Pharmacology Forum (CNCPL Forum) convened in June to discuss both current and upcoming CPQA proficiency testing rounds, including compendial testing and TB panel development. Additionally, the Forum continued deliberations on whether a hemolysis level exceeding 2% should be a standard rejection criterion for PK plasma samples. The group also discussed the upcoming publication of the CPQA’s updated guidelines for bioanalytical method validation, as well as the accompanying training module.
In June, the Lab Focus Group (LFG) convened to address issues related to lab supply shortages, regulatory requirements for document archiving at lab sites, and ongoing efforts to publish a new version of the Cross-Network Peripheral Blood Mononuclear Cell (PBMC) Processing Standard Operating Procedure (SOP).
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Brian Minalga
HANC
Deputy Director
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Cat Banobi
Legacy
Project Manager
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Gabriella Olague
HANC
Project Coordinator
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June 2024: HANC and The Legacy Project had two abstracts accepted to HIV R4P!
We can’t wait to head to Lima, Peru this October to present the following work:
- Wednesday, October 9, 6:30 - 8:30 p.m. in-person poster exhibition: “Evaluating an historically Black college and university (HBCU)-based initiative to promote careers in HIV prevention research” (poster exhibition October 8-9)
- Thursday, October 10, 8:30 to 10 a.m. in Session Room 3: “The Transgender Scorecard: Ensuring Representation in HIV Prevention Research” (oral, in-person session)
July 22-26: Brian Minalga will represent HANC and The Legacy Project at AIDS 2024, the 25th International AIDS Conference.
Brian–and HANC’s favorite drag queen, Miss Molly Moon–will be providing media coverage of the conference in collaboration with the NIAID Communications Office and HIV.gov. You can follow along on the HIV.gov blog and social media accounts.
You will also find Brian in the Global Village at AIDS 2024; come see Brian at the HPTN/HVTN Networking Zone (Location HT06) from 4 to 4:30 p.m. on Monday, July 22 where they are speaking with Dr. Asa Radix on the topic of addressing the unique needs of transgender and gender-diverse people in HIV prevention research.
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AIDS 2024 (Munich, Germany)
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Community Partners Meeting (Arlington, USA)
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IMPAACT Annual Network Meeting (Arlington, USA)
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